It is estimated that there are more than 1000 strains of bacteria in human intestines. The whole community of bacteria is called microbiota. It has been reported that the function of the gut microbiota is related to various health conditions of humans including obesity, colon cancer and mental illness. Dynamically assessing and understanding various changes in gut microbiota will lead to the discovery, prevention and treatment of these diseases. However, it is very difficult to assess the gut microbiota in which a wide variety of bacteria exist, and the whole picture is unknown.
- In order to dynamically comprehend gut microbiota, it is necessary to acquire comprehensive data of gut microbiota such as strain and proportion of bacteria, the genetic function and sequential change of metabolite; and integrated omics analysis is also required to find the relation to health conditions and the meaning of the change. We use metagenomic data that are acquired using the next generation sequencer and comprehensive metabolite data acquired using the mass spectrometer. We perform principal component analysis, hierarchical clustering and network analysis based on the obtained data.
- For data analysis of microbiome, we utilize the databases of microorganisms potentially involved in oxidation-reduction of nitrogen and sulfur and that of microorganisms whose substrates and products are known. We are also updating the databases every day.
- We are working with Japan Microbiome Consortium (JMBC) to prepare recommended analysis protocols and develop standard substances for human microbiome analysis.
- We are developing competitive analytical technology by establishing our own database.
New Energy and Industrial Technology Development Organization (NEDO), Japan Microbiome Consortium (JMBC)